Add the ground beef to a skillet over medium heat. When halfway cooked, sprinkle on onion powder, garlic powder, salt and pepper. Cook until no longer pink.
Drain grease from the beef, if needed.
Arrange the tortilla chips in a layer completely covering the bottom of a baking sheet.
Spoon the beef evenly over the chips and sprinkle with cheese.
Place the pan in the oven for about 5 minutes to melt the cheese.
Remove from the oven and top with lettuce, pickles and onion.
Use a spoon to drizzle the Mac sauce over the top.
Serve immediately.
Mac Sauce:
Whisk together all of the ingredients in a small bowl.
Store leftovers covered in the fridge for up to a week.